The reference site for Paroxetine

Paroxetine, also known by the trade names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

WHAT IS Paroxetine?

This new site is dedicated exclusively to paroxetine.

It provides you with the most extensive product information and up-to-date resources regarding this medication, including related news articles, medical studies, an image library and all the necessary information on dosage and side effects.

Whether you are an average consumer or a pharma industry professional, you can now find out everything you need to know about paroxetine , as well as take part in our open discussion forum by sharing your own knowledge and experiences with people who are using this medication.

This unique site will also provide you with inside industry news on which companies or organizations are playing an important part in its research, development, production and promotion. It is your one-stop site for a total paroxetine experience!


Brand Name(s): Paxil; Seroxat
CAS nº: 61869-08-7
(pa ROX a teen)


Product Info

The sections below will provide you with more specific information and guidelines related to paroxetine and its correct use. Please read them carefully.

FDA Information

Paroxetine was the first (and as of 2002, the only) antidepressant formally approved in the United States for the treatment of social anxiety disorder, a highly debilitating condition that affects more than 10 million Americans.

Paxil® is also approved in the United States for the treatment of post-traumatic stress disorder (PTSD).

Why is this medication prescribed?

Paroxetine hydrochloride is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

Paroxetine is an anti-depressant drug that affects the chemicals that nerves in the brain use to communicate with one another. These chemical messengers, called neurotransmitters, are released by one nerve and taken up by other nerves. Neurotransmitters that are released but not taken up by other nerves are taken up by the nerves that release them (“reuptake”).

Many experts believe that it is an imbalance among the amounts of the different neurotransmitters that are released that causes depression. Paroxetine works by inhibiting the reuptake of serotonin by the nerves that release it, an action which allows more serotonin to be available to be taken up by other nerves.

Paroxetine is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that also contains fluoxetine (Prozac®) and sertraline (Zoloft®).

Other uses for this medicine

Paroxetine is also sometimes used to treat chronic headaches, tingling in the hands and feet caused by diabetes, and certain male sexual problems.

Moreover, this medication is also used with other medications to treat bipolar disorder (mood that changes from depressed to abnormally excited).

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Paroxetine comes as a tablet, a suspension (liquid), and a controlled-release (long-acting) tablet that is taken orally.

It is usually taken once daily in the morning or evening, with or without food. You may want to take paroxetine with food to stop it from upsetting your stomach.

To help you remember to take paroxetine, take it around the same time every day.

Always follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take paroxetine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly.

Swallow the extended-release tablets whole – never split, chew, or crush them.

Your doctor may start you on a low dose of paroxetine and gradually increase your dose, not more than once a week.

It is important to know that paroxetine controls your condition but does not cure it. It may take several weeks or longer before you feel the full benefit of paroxetine. Continue to take paroxetine even if you feel well. Do not stop taking paroxetine without talking to your doctor.

Additionally, your doctor will probably decrease your dose gradually. If you suddenly stop taking paroxetine, you may experience withdrawal symptom.

What special precautions should I follow?


Tell your doctor and pharmacist if you are allergic to paroxetine or any other medications.

Do not take paroxetine if you are taking monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan®), phenelzine (Nardil®), selegiline (Eldepryl®), and tranylcypromine (Parnate®), or have stopped taking them within the past two weeks. If you stop taking paroxetine, you should wait at least 2 weeks before you start to take an MAO inhibitor.

Do not take paroxetine if you are taking thioridazine (Mellaril®).

Always inform your doctor and pharmacist what other prescription and non-prescription medications and vitamins you are taking. Be sure to mention any of the following: anticoagulants (‘blood thinners’) such as warfarin (Coumadin®); antidepressants (mood elevators) such as amitriptyline (Elavil®), amoxapine (Asendin®), clomipramine (Anafranil®), desipramine (Norpramin®), doxepin (Adapin®, Sinequan®), imipramine (Tofranil®), nortriptyline (Aventyl®, Pamelor®), protriptyline (Vivactil®), and trimipramine (Surmontil®); antihistamines; aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil®, Motrin®), and naproxen (Aleve®, Naprosyn®); atazanavir (Reyataz®); bromocriptine (Parlodel®); bupropion (Wellbutrin®); buspirone (Buspar®); celecoxib (Celebrex®); chlorpromazine (Thorazine®); cimetidine (Tagamet®); clopidogrel (Plavix®); codeine (found in many cough and pain medications); dexamethasone (Decadron®); dextromethorphan (found in many cough medications); diazepam (Valium®); dicloxacillin (Dynapen®); digoxin (Lanoxin®); dipyridamole (Persantine®); diuretics (‘water pills’); haloperidol (Haldol®); isoniazid (INH, Nydrazid®); lithium (Eskalith®, Lithobid®); medications for irregular heartbeat such as amiodarone (Cordarone®, Pacerone®), encainide (Enkaid®), flecainide (Tambocor®), mexiletine (Mexitil®), moricizine (Ethmozine®): propafenone (Rythmol®), and quinidine (Quinidex®); medications for mental illness and nausea; medications for seizures such as phenobarbital (Luminal®, Solfoton®) and phenytoin (Dilantin®); meperidine (Demerol®); methadone (Dolophine®); metoclopromide (Reglan®); metoprolol (Lopressor®, Toprol XL®); odansetron (Zofran®); other selective serotonin reuptake inhibitors such as citalopram (Celexa®), fluoxetine (Prozac®, Sarafem®); fluvoxamine (Luvox®); and sertraline (Zoloft®); pimozide (Orap®); procyclidine (Kemadrin®); propoxyphene (Darvon®); propranolol (Inderal®); ranitidine (Zantac®); rifampin (Rifadin®, Rimactane®); risperidone (Risperdal®); ritonavir (Norvir®); sumatriptan (Imitrex®); tamoxifen (Nolvadex®); terbinafine (Lamisil®); theopylline (Theobid®, Theo-Dur®); ticlopidine (Ticlid®); timolol (Blocadren®); tramadol (Ultram®); trazodone (Desyrel®); and venlafaxine (Effexor®). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor what herbal products and nutritional supplements you are taking, especially St. John’s wort and tryptophan.

Tell your doctor if you or anyone in your family has or has ever had depression, bipolar disorder (mood that changes from depressed to abnormally excited), or mania (frenzied, abnormally excited mood), or if you or anyone in your family has thought about or attempted suicide.

It is important that you also inform your doctor if you use or have ever used street drugs or have overused prescription medications, if you have recently had a heart attack, and if you have or have ever had glaucoma (an eye disease); seizures; bleeding from your stomach or esphagus (tube that connects the mouth and stomach) or liver, kidney, or heart disease.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking paroxetine, call your doctor.

You should know that paroxetine may make you drowsy and affect your judgment and thinking. Do not drive a car or operate machinery until you know how this medication affects you.

Ask your doctor about the safe use of alcoholic beverages while you are taking paroxetine.

Additionally, you should be aware that your mental health may change in unexpected ways, especially at the beginning of your treatment and any time that your dose is increased or decreased. These changes may occur at any time if you have depression or another mental illness, whether or not you are taking paroxetine or any other medication. You, your family, or caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed.

Never take extra medicine to make up the missed dose.

What side effects can this medication cause?

Side effects from paroxetine may include the following:

dry mouth
decreased or eliminated sexual desire
delayed or eliminated orgasm
reduction in sexual desire and capacity
sodium depletion
changes in urination
changes in appetite

Tell your doctor if any of these symptoms are severe or do not go away:

sleepiness or insomnia
decreased sex drive
difficulty having an orgasm
dry mouth
anxiety trouble concentrating
changes in appetite or weight

If you experience any of the following symptoms, call your doctor immediately:

difficulty breathing
closing of the throat
swelling of the lips, tongue, or face; or hives
low blood pressure
high blood pressure
unusual bleeding or bruising
fever or chills

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. Please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call the local emergency services on 911.

Symptoms of overdose may include:

rapid or weak heartbeat
decreased urination
muscle stiffness or weakness
enlarged pupils

Product Images


Below you will find images and specific information on the principal types of paroxetine that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PAXIL®
Strength(s): 10 MG
Imprint: PAXIL 10

Strength(s): 10 MG
Imprint: 9|3 7144
Manufacturer: TEVA USA

Name: PAXIL®
Strength(s): 12.5 MG
Imprint: PAXIL CR 12.5

Name: PAXIL®
Strength(s): 20 MG
Imprint: PAXIL 20

Strength(s): 20 MG
Imprint: APO 083
Manufacturer: APOTEX CORP.

Strength(s): 20 MG
Imprint: par 877
Manufacturer: PAR PHARM.

Strength(s): 20 MG
Imprint: 9|3 7115
Manufacturer: TEVA USA

Name: PAXIL®
Strength(s): 25 MG
Imprint: PAXIL CR 25

Strength(s): 30 MG
Imprint: G P3
Manufacturer: ANDRX PHARM.

Strength(s): 30 MG
Imprint: APO 084
Manufacturer: APOTEX CORP.

Name: PAXIL®
Strength(s): 37.5 MG
Imprint: PAXIL CR 37.5

Strength(s): 40 MG
Imprint: APO 101
Manufacturer: APOTEX CORP.

Strength(s): 40 MG
Imprint: par 879
Manufacturer: PAR PHARM.

Strength(s): 40 MG
Imprint: 93 7121
Manufacturer: TEVA USA

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